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 Nalvi  Duro

Nalvi Duro

Nalvi Duro

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Advisor : Sameer Varma

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Ph.D.

Paramyxoviruses include notable pathogens such as Measles, Nipah, and Newcastle disease virus that infect both humans and animals. Paramyxoviruses use the concerted action of two membrane proteins to infect, a receptor binding protein (RBP) and a fusion (F) protein. Upon binding of the receptor, the RBP activates F to carry out fusion of the host and cell membranes. The receptor binding site and the f activating site on the RBP are separated by >2 nm. Moreover, experiments suggest that receptor binding induces negligible structural changes within the RBP monomers, suggesting that a change in dynamics may play a central role in signal transmission between the two sites. I use computational tools to understand the dynamic allostery that links the receptor binding and the F activating sites in the Newcastle RBP.