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 Carly  Harro

Carly Harro

Carly Harro



Advisor : Alvaro Monteiro



Genome wide association studies (GWAS) have identified genomic loci associated with breast and ovarian cancer risk, however, the vast majority of associated variants reside in non-coding regions. The molecular mechanisms by which they cause susceptibility are unknown. My work is focused on performing functional analysis breast and ovarian susceptibility loci to explore the regulatory landscape of these loci and provide a mechanistic basis to understand susceptibility in breast and ovarian cancer. I am also interested in elucidating the overall function of enhancer RNAs, a subset of non-coding RNAs transcribed at enhancer regions, and whether this function is influenced by the allelic states of overlapping GWAS variants.