banner USF Home College of Arts & Sciences OASIS myUSF USF A-Z Index

USF Home > College of Arts and Sciences > Department of Cell Biology, Microbiology and Molecular Biology

 Christina   Moss

Christina Moss

Christina Moss

Contact

Email:

Advisor : Charles Chalfant

Program

Ph.D.

My current research focuses on the role that RNA alternative splicing plays in the progression of breast and lung cancer. About 1 in 8 women will develop breast cancer in her lifetime, and roughly 1 in 15 men or 1 in 17 women will develop lung cancer in his or her lifetime. Current drug therapies struggle to treat these common and high-mortality cancers due to their heterogeneous genomic and transcriptomic profiles, Hence, personalization of therapeutic regimens requires a multi-omics approach. Using deep RNA sequencing data, I aim to identify both alternative mRNA splicing and non-coding RNA pathways which play key roles in tumor development and metastasis through 3 projects: 1) The role of alternative mRNA splicing and non-coding RNA pathways in non-transformed breast cells compared to tumorigenic breast cancer cell lines, 2) The role of alternative mRNA splicing in non-coding RNA pathways in various lung cancer oncogenotypes including Kras and p53 mutants, and 3) The role of alternative mRNA splicing in non-coding RNA pathways in a murine breast cancer Cers4 knockout model.