Meera Nanjundan
Meera Nanjundan
Assistant Professor
Contact
Office: BSF 165
Phone: 813/974-8133
Email:
Links
Education
B.Sc (Honours), Queen’s University at Kingston, Ontario, CANADA, 1992-1996
Ph.D, University of Western Ontario, London, Ontario, CANADA, 1996-2001
Postdoctoral Fellow, The Scripps Research Institute, La Jolla, California, 2001-2003
Postdoctoral Fellow, MD Anderson Cancer Center, Houston, Texas, 2003-2007
Research Assistant Professor, MD Anderson Cancer Center, Houston, Texas, 2007
Research
Our research focuses on the study of specific genes located at the 3q26.2 locus which are aberrantly expressed at the DNA, RNA, and protein level in epithelial cancer development. These genes of interest are mediators in the TGF-beta signaling pathway. Our goal is to improve our understanding of the role of these as well as other TGF-beta signaling mediators during cancer development and the mechanism by which they are regulated. Cross-talk between the TGF-beta signaling pathway and other signaling pathways aberrant in cancer is one area of current research focus. To address these research areas, our laboratory is utilizing a number of experimental approaches including in vitro cellular studies, studies with model organisms, as well as a variety of proteomic approaches.
Graduate Students
Punashi Dutta, Kodigepall Karthik
Recent Publications
Byers LA, Sen B, Saigal B, Diao L, Wang J, Nanjundan M, Cascone T, Mills GB, Heymach JV, Johnson FM.
Reciprocal regulation of c-Src and STAT3 in non-small cell lung cancer.
Clin Cancer Res. 2009 Nov 15;15(22):6852-61.
Nanjundan M, Zhang F, Lahad J, Kuo W, Schmandt R, Smith-McCune K, Fishman D, Gray JW, Mills GB.
Overexpression of SnoN/SkiL, Amplified at the 3q26.2 Locus in Ovarian Cancers: Role in Ovarian Pathogenesis.
Molecular Oncology, 2008 Aug; 2(2):164-181.
Hennessy BT, Murph M, Nanjundan M, Carey M, Auersperg N, Almeida J, Coombes KR, Liu J, Lu Y, Gray JW, Mills GB.
Ovarian cancer: linking genomics to new target discovery and molecular markers--the way ahead.
Adv Exp Med Biol. 2008; 617:23-40.
Nanjundan M, Nakayama Y, Cheng KW, Lahad J, Liu J, Lu K, Kuo WL, Smith-McCune K, Fishman D, Gray JW, Mills GB.
Amplification of MDS1/EVI1 and EVI1, located in the 3q26.2 amplicon, is associated with favorable patient prognosis in ovarian cancer.
Cancer Res. 2007 Apr 1;67(7):3074-84.
Nanjundan M, Zhang F, Schmandt R, Smith-McCune K, Mills GB.
Identification of a novel splice variant of AML1b in ovarian cancer patients conferring loss of wild-type tumor suppressive functions.
Oncogene. 2007 Apr 19;26(18):2574-84.
Hennessy BT, Nanjundan M, Cheng KW, Nolden L, Mills GB.
Identification of remodeling and spacing factor 1 (rsf-1, HBXAP) at chromosome 11q13 as a putative oncogene in ovarian cancer.
Eur J Hum Genet. 2006 Apr;14(4):381-3.
Nanjundan M, Sun J, Zhao J, Zhou Q, Sims PJ, Wiedmer T.
Plasma membrane phospholipid scramblase 1 promotes EGF-dependent activation of c-Src through the epidermal growth factor receptor.
J Biol Chem. 2003 Sep 26;278(39):37413-8.
Wiedmer T, Zhao J, Nanjundan M, Sims PJ.
Palmitoylation of phospholipid scramblase 1 controls its distribution between nucleus and plasma membrane.
Biochemistry. 2003 Feb 11;42(5):1227-33.
Nanjundan M, Possmayer F.
Pulmonary phosphatidic acid phosphatase and lipid phosphate phosphohydrolase.
Am J Physiol Lung Cell Mol Physiol. 2003 Jan;284(1):L1-23.
Sun J, Nanjundan M, Pike LJ, Wiedmer T, Sims PJ.
Plasma membrane phospholipid scramblase 1 is enriched in lipid rafts and interacts with the epidermal growth factor receptor.
Biochemistry. 2002 May 21;41(20):6338-45.
Nanjundan M, Possmayer F.
Molecular cloning and expression of pulmonary lipid phosphate phosphohydrolases.
Am J Physiol Lung Cell Mol Physiol. 2001 Dec;281(6):L1484-93.
Nanjundan M, Possmayer F.
Pulmonary lipid phosphate phosphohydrolase in plasma membrane signalling platforms.
Biochem J. 2001 Sep 15;358(Pt 3):637-46.
Nanjundan M, Possmayer F.
Characterization of the pulmonary N-ethylmaleimide-insensitive phosphatidate phosphohydrolase.
Exp Lung Res. 2000 Jul-Aug;26(5):361-81.